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After a median follow-up of 68 months, anastrozole significantly prolonged disease-free survival (575 events with anastrozole vs 651 with tamoxifen, hazard ratio 0·87, 95% CI 0·78–0·97, p=0·01) and time-to-recurrence (402 vs 498, 0·79, 0·70–0·90, p=0·0005), and significantly reduced distant metastases (324 vs 375, 0·86, 0·74–0·99, p=0·04) and contralateral breast cancers (35 vs 59, 42% reduction, 12–62, arimidex p=0·01) .
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Anastrozole should be the preferred initial treatment for postmenopausal women arimidex with localised hormone-receptor-positive breast cancer .
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Disease-free survival arimidex Time-to-recurrence Time-to-distant-recurrence Overall survival Time to breast cancer death Contralateral breast cancer* 0·6 0·8 1·0 1·2 1·5 Hazard ratio (A/T) and 95% CI Proportion with recurrence (%) Hazard ratio 0·74 (95% CI 0·64–0·87) Follow-up time (years) Numbers at risk: Anastrozole 2618 Figure: (A) Efficacy endpoints for all patients and hormone-receptor-positive patients and (B) time-to-recurrence in hormone-receptor-positive patients A=anastrozole .
arimidex *Odds ratio calculated instead of hazard ratio .

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