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    Possible Functions of Postsynaptic Serotonin Receptors Appetite, obesity Stahl trazodone SM .
    Trends in Psychopharmacology The theoretical functions trazodone orange juice trazodone overdose management trittico varesino cost of desyrel trazodon jak linked to 3 key serotonin receptors 5-HT1A receptors desensitize so antidepressant efficacy is generally sustained (Figure 5) .
    ” Hypothetically, unwanted desensitization of post synaptic 5-HT1A receptors could be linked to this loss of efficacy after long trazodone term drug administration . However, antidepressant efficacy of SSRIs/SNRIs is lost over time in trazodone some patients, a phenomenon sometimes called “poop-out .
    Postsynaptic 5-HT2A and 5-HT2C receptors often desensitize as well in many patients after long term administration of SSRIs/SNRIs, hypothetically leading to abatement of some side effects linked trittico quadri per arredare trazodone vs xanax for sleep trazodone classification trazodon 50 mg to these receptors, especially anxiety (Figures 4B, 4C, and 5) .
    9 Sexual dysfunction trazodone can wane with chronic administration of SSRIs/SNRIs but in many patients is a persistent problem . Insomnia, on the other hand, is not as readily improved after long term treatment with SSRIs/SNRIs and in fact is the most common trazodone residual symptom after treatment with these agents .
    In summary, by raising serotonin at all serotonin receptors and in all brain areas, trazodone SERT inhibitors such as SSRIs and SNRIs simultaneously cause antidepressant actions by stimulating 5-HT 1A receptors, but side effects by stimulating 5-HT 2A and 5-HT 2C receptors (Figures 4 and 6) .
    However, when SERT inhibition is combined with 5-HT2A/2C inhibition, this leads to antidepressant actions without sexual dysfunction, anxiety, or insomnia (Figure trazodone 7) .

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