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[28] Folic acid is needed for the de Trexall novo synthesis of the nucleoside thymidine, required for DNA synthesis . [28] Also, folate is essential for purine Trexall and pyrimidine base biosynthesis, so synthesis will be inhibited . methotrexate injection side effects rheumatoid arthritis methotrexate tongue sores methotrexate DHFR catalyses the conversion of dihydrofolate to the active tetrahydrofolate .
[28] Image shows open bottle of methotrexate drugone of the first chemotherapeutic drugs can methotrexate cause cancer methotrexate headache side effect alcohol and methotrexate weight loss used in the early 1950s In 1947, a team of researchers led by Sidney Farber showed aminopterin, a chemical analogue of folic acid developed by Yellapragada Subbarao of Lederle, could induce remission in children with acute lymphoblastic leukemia . Methotrexate, therefore, inhibits the synthesis of DNA, RNA, thymidylates, and Trexall proteins .
The development of folic acid analogues had been prompted by the discovery that the administration of folic acid worsened leukemia, and that a diet deficient in folic acid could, conversely, produce improvement; the mechanism of methotrexate time to effect methotrexate hair loss methotrexate tablets side effects methotrexate action behind these effects was still unknown at the time . [33] Other analogues of folic acid were in development, Trexall and by 1950, methotrexate (then known as amethopterin) was being proposed as a treatment for leukemia . [34] Animal studies published in 1956 showed the therapeutic index of methotrexate was better than that of aminopterin, and clinical use of aminopterin was thus abandoned in favor methotrexate 10 mg tablets side effects methotrexate and weight loss methotrexate injection brand of methotrexate .
In 1951, Trexall Jane C .

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