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    Commercial Name: Cozaar Active Ingredient: LosartanUtilization: Used for treating high blood pressure alone or with other medicinesAvailable Dosages: 25mg and 50mgCommercial Name: HyzaarActive Ingredient: LosartanUtilization: Used for treating high blood pressure alone or with other medicines

    Drug interactions

    Ketoconazole did not affect the conversion of losartan to the active metabolite after intravenous administration of losartan, and erythromycin valsartan bijsluiter losartan long term side effects cozaar 100 mg cost valsartan sigma hyzaar dose had no clinically significant effect after oral administration .
    Fluconazole, an inhibitor of P450 2C9, decreased active metabolite concentration and increased losartan losartan y amlodipino losartan 100 mg oral tablet valsartan para que sirven losartan medscape concentration .
    The pharmacodynamic consequences of concomitant use of losartan and inhibitors of P450 2C9 have not been losartan examined .
    Subjects who do not metabolize losartan to active metabolite losartan have been shown to have a specific, rare defect in cytochrome P450 2C9 .
    These data suggest that the conversion of losartan to its active metabolite is mediated primarily by P450 2C9 and losartan not P450 3A4 .
    , spironolactone, triamterene, amiloride), potassium supplements, or salt substitutes containing potassium may lead to losartan increases in serum potassium . As with other drugs that block angiotensin II or its losartan effects, concomitant use of potassium-sparing diuretics (e .
    Lithium: As with losartan other drugs which affect the excretion of sodium, lithium excretion may be reduced .
    Therefore, serum lithium levels should be monitored carefully if lithium salts are to be co-administered with angiotensin II receptor losartan antagonists .
    Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) Including Selective Cyclooxygenase-2 Inhibitors (COX-2 Inhibitors): In patients who are elderly, volume-depleted (including those on diuretic therapy), or with compromised renal function, co-administration of NSAIDs, including selective COX-2 inhibitors, with angiotensin II receptor antagonists (including losartan losartan) may result in deterioration of renal function, including possible acute renal failure .

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