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After a median follow-up of 68 months, anastrozole significantly prolonged disease-free survival (575 events with anastrozole vs 651 with tamoxifen, hazard ratio arimidex 0·87, 95% CI 0·78–0·97, p=0·01) and time-to-recurrence (402 vs 498, 0·79, 0·70–0·90, p=0·0005), and significantly reduced distant metastases (324 vs 375, 0·86, 0·74–0·99, p=0·04) and contralateral breast cancers (35 vs 59, 42% reduction, 12–62, p=0·01) .
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