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In the "all" oxycodone CR group, the tapentadol most frequently reported severe TEAEs were constipation (42/464 subjects), somnolence (24/240 subjects) and vomiting (37/292 subjects) .
tapentadol erowid tapentadol grunenthal colombia tapentadol canada tapentadol wales tapentadol usp No differences in the safety profile were observed in age or gender Adverse Events with Prolonged Treatment Study PAI-3007/KF24 investigated subjects for up to one year using an open-label design and a 4:1 randomisation to either tapentadol SR (dose range 100 mg to 250 mg) or oxycodone CR (dose range 20 mg to 50 mg) administered by controlled adjustment of dose .
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7%) than in the tapentadol oxycodone CR group (90 . The overall incidence of TEAEs was lower in the tapentadol tapentadol SR group (85 .

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