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Commercial Name: Cozaar Active Ingredient: LosartanUtilization: Used for treating high blood pressure alone or with other medicinesAvailable Dosages: 25mg and 50mgCommercial Name: HyzaarActive Ingredient: LosartanUtilization: Used for treating high blood pressure alone or with other medicines

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There is also an AT2 receptor losartan found in many tissues but it is not known to be associated with cardiovascular homeostasis .
Both losartan and its principal active metabolite Reference ID: 3283103 COZAAR® (LOSARTAN POTASSIUM TABLETS) do not exhibit any partial agonist activity at the AT1 receptor and have much greater affinity losartan 50 mg pra que serve valsartan tabletki hyzaar weight gain valsartan y alcohol losartan (about 1000-fold) for the AT1 receptor than for the AT2 receptor .
In vitro losartan binding studies indicate that losartan is a reversible, competitive inhibitor of the AT1 receptor .
The losartan active metabolite is 10 to 40 times more potent by weight than losartan and appears to be a reversible, non-competitive inhibitor of the AT1 receptor .
Neither losartan nor its active metabolite inhibits ACE (kininase II, valsartan ratiopharm 320 mg hyzaar package insert cozaar with food cozaar routes of administration the enzyme that converts angiotensin I to angiotensin II and degrades bradykinin); nor do they bind to or block other hormone receptors or ion channels known to be important in cardiovascular regulation .
Pharmacokinetics Losartan is an orally active agent that undergoes valsartan vaistai valsartan medication losartan 50 mg bogota valsartan structure valsartan substantial first-pass metabolism by cytochrome P450 enzymes .
It is converted, in part, to an active losartan carboxylic acid metabolite that is responsible for most of the angiotensin II receptor antagonism that follows losartan treatment .
Losartan metabolites losartan have been identified in human plasma and urine .
In addition to the active carboxylic acid metabolite, losartan several inactive metabolites are formed .
Following oral and intravenous administration of 14C-labeled losartan losartan potassium, circulating plasma radioactivity is primarily attributed to losartan and its active metabolite .

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